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I don't know how mankind can be responsible in the ultimate sense of the word since they were "made sinners" against their will (Rom.5:19; 8:20). They cannot not sin. All sin and are wanting of the glory of God.

A couple of points:

[*]Rom. 5:19, "For as through one man's disobedience the many were made sinners" does not imply that this is against our will. Adam sinned willingly, did he not? And in our fallen state, we ratify Adam's disobedience by following in his footsteps. Men will evil---it is the desire of our hearts continually (Gen.6:5).
[*]Rom. 8:20, "For the creation was subjected to futility, not willingly," refers to creation as a whole and apart from man.

Kyle

I tell you, this man went down to his house justified.